Barkley is done for the year due to an ACL tear after playing in less than two games. This will be his second season plagued by injuries as he was hampered by a high ankle sprain last year. Dion Lewis and Wayne Gallman will split the lead-back duties for now. Lewis showed off some serious burst and quick cuts while in New England but failed to replicate that magic with the Tennessee Titans. He also has great hands for a running back. Lewis is the preferred waiver wire pick up of the two but Gallman still deserves to be rostered in every league.
Christian McCaffrey suffered an ankle injury that prevented him from closing out the Panthers' loss to Tampa Bay. He is expected to miss 4-6 weeks. He notched two scores for his fantasy backers before leaving the game. Mie Davis is the backup to CMC but Curtis Samuel could also get some run out of the backfield. Samuel played RB early in his college career before transitioning to receiver later in his time at Ohio State. He's been wildly effective on the limited carries he's seen as a pro. Davis caught all eight of his targets in Week 2 while doing his best CMC impression. He and Lewis are the two best adds off the waiver wire this week.
Rams rookie Cam Akers did not finish the team's game versus Philly due to a rib injury. Darrell Henderson showed up in the box score with an impressive 121 yards and a touchdown on 14 touches. Malcolm Brown carried the ball 11 times for 47 yards and added nothing through the air. This is mostly a backfield to avoid but Henderson is likely a free agent in some fantasy leagues. He's worth snagging off waivers if Akers is expected to be out multiple weeks. Henderson will still share the backfield with Brown but his pass-catching upside is worth chasing.
Parris Campbell suffered a scary knee injury at the beginning of the Colts matchup versus the Vikings. He appears to have avoided a catastrophic injury as reports have now added that he did not tear anything in his knee. Campbell will likely be sidelined multiple weeks at a minimum and can probably be dropped for some of the better waiver adds this week. T.Y. Hilton will resume his role as the No. 1 receiver in Indy while second-round rookie Michael Pittman and Zach Pascal battle for the No. 2 job.
Davante Adams missed the second half of Green Bay's game versus the Lions with an ankle injury. The Packers were burying the Lions by halftime so there was little need for Adams to come back into the game. He should be able to play in Week 3 but his status is one to monitor as Green Bay gets back to practice early in the week.
Drew Lock suffered a shoulder injury that is expected to sideline him for 2-6 weeks. Jeff Driskel played most of the Broncos' Week 2 matchup versus the Steelers and managed to find the end zone twice. Don't expect this to be the norm as Driskel has failed as a backup in Detroit and Cincinnati. All Broncos fantasy weapons are downgraded without Lock under center
The 49ers starting quarterback suffered an ankle injury that looks to be keeping him out of Week 3 but the team does have some hope that he'll play. A Week 4 return should be the projection for him though. Nick Mullens will start while he's out. Mullens started eight games in 2018 while Jimmy Garoppolo was out and was serviceable but a downgrade none the less. Much like the Broncos, don't expect explosive games from this offense while Mullens is under center.
The 49ers also lost Raheem Mostert but the initial reports have indicated that his injury is a short-term ordeal. Moster broke off an 80-yard run to open their trouncing of the Jets but did not return after halftime. Tevin Coleman will see the bulk of the carries between the tackles but don't rule out Jerick McKinnon from getting extra touches either. McKinnon was the more electric back in Week 2. He notably converted on a 3rd and 31 for San Francisco and also scored once. He's a priority addition off the waiver wire for short-term value.
Sterling Shepard popped up with another soft tissue injury in Week 2. This time it was his toe and the team believes he could miss games. Darius Slayton appears solidified as the No. 1 receiver for the Giants and has splash-play upside on every target he sees. Evan Engram and Golden Tate are passable options in PRR leagues but the output of the Giants offense leaves a lot to be desired.
Breshad Perriman suffered an ankle injury that cost him most of Week 2 but Jets players are bad bets even if they manage to stay healthy. The Jets looked completely lost against a talented 49ers defensive unit in Week 2. It didn't help that they lost most of their skill position players by the end of the game. Any team coached by Adam Gase with Sam Darnold under center should be avoided in fantasy.