| Player | Comp/Att | Ps-Yards | Ps-TDs | int |
| Garoppolo, Jimmy | 27/41 | 296 | 2 | 0 |
|
| Player | Comp/Att | Ps-Yards | Ps-TDs | int |
| Burrow, Joe | 25/34 | 348 | 2 | 0 |
|
| Player | Att | Yards | ave | TDs |
| Wilson, Jarrod | 13 | 56 | 4.3 | 0 |
| Wilson Jr., Jeff | 13 | 56 | 4.3 | 0 |
| Samuel, Deebo | 8 | 37 | 4.6 | 1 |
| Aiyuk, Brandon | 1 | 4 | 4.0 | 0 |
| Garoppolo, Jimmy | 1 | 3 | 3.0 | 0 |
|
| Player | Att | Yards | ave | TDs |
| Mixon, Joe | 18 | 58 | 3.2 | 0 |
| Perine, Samaje | 4 | 11 | 2.8 | 0 |
| Boyd, Tyler | 1 | 8 | 8.0 | 0 |
| Chase, Ja'Marr | 1 | 6 | 6.0 | 0 |
| Burrow, Joe | 2 | 3 | 1.5 | 0 |
|
| Player | T/Rec | Yards | ave | TDs |
| Kittle, George | 15/13 | 151 | 11.6 | 1 |
| Aiyuk, Brandon | 10/6 | 62 | 10.3 | 1 |
| Jennings, Jauan | 5/3 | 46 | 15.3 | 0 |
| Samuel, Deebo | 1/1 | 22 | 22.0 | 0 |
| Hasty, JaMycal | 3/3 | 10 | 3.3 | 0 |
| Juszczyk, Kyle | 2/1 | 5 | 5.0 | 0 |
|
| Player | T/Rec | Yards | ave | TDs |
| Higgins, Tee | 7/5 | 114 | 22.8 | 0 |
| Chase, Ja'Marr | 8/5 | 77 | 15.4 | 2 |
| Uzomah, C.J. | 6/4 | 56 | 14.0 | 0 |
| Boyd, Tyler | 5/4 | 55 | 13.8 | 0 |
| Perine, Samaje | 5/4 | 22 | 5.5 | 0 |
| Sample, Drew | 1/1 | 14 | 14.0 | 0 |
| Mixon, Joe | 2/2 | 10 | 5.0 | 0 |
|
| Player | XP/XA | FG/FGa | 1-39 | 40-49 | 50+ | FSV |
| Gould, Robbie | 2/2 | 2/3 | 2/2 | 0/1 | 0/0 | 8 |
|
| Player | XP/XA | FG/FGa | 1-39 | 40-49 | 50+ | FSV |
| McPherson, Evan | 2/2 | 3/4 | 2/2 | 1/2 | 0/0 | 11 |
|
| Player | Fum | F lost | F Rec | F Forc | F TDs |
| Ebukam, Samson | 0 | 0 | 0 | 1 | 0 |
|
| Player | Fum | F lost | F Rec | F Forc | F TDs |
| Bell, Vonn | 0 | 0 | 0 | 1 | 0 |
|
| Player | Int | Ret. Yds. | Ret. TDs |
No Interceptions |
|
| Player | Int | Ret. Yds. | Ret. TDs |
No Interceptions |
|
| Player | Tackles | Assists | Sacks |
| Al_Shaair, Azeez | 8 | 3 | 1 |
| Williams, K'Waun | 5 | 2 | 1 |
| Hufanga, Talanoa | 4 | 1 | 0 |
| Ward, Jimmie | 3 | 2 | 0 |
| Tartt, Jaquiski | 3 | 4 | 0 |
| Armstead, Arik | 2 | 2 | 0 |
| Bosa, Nick | 2 | 1 | 2 |
| Norman, Josh | 2 | 1 | 0 |
| Jones, D.J. | 2 | 3 | 0 |
| Thomas, Ambry | 2 | 4 | 0 |
| Lenoir, Deommodore | 1 | 0 | 0 |
| Omenihu, Charles | 1 | 0 | 0 |
| Givens, Kevin | 1 | 0 | 0 |
| Harris, Marcell | 1 | 1 | 0 |
| Warner, Fred | 1 | 6 | 0 |
| Ebukam, Samson | 0 | 3 | 0.5 |
| Willis, Jordan | 0 | 3 | 0 |
| Key, Arden | 0 | 1 | 0.5 |
|
| Player | Tackles | Assists | Sacks |
| Bates III, Jessie | 8 | 1 | 0 |
| Bell, Vonn | 5 | 5 | 0 |
| Pratt, Germaine | 4 | 5 | 0 |
| Awuzie, Chidobe | 4 | 2 | 0 |
| Ogunjobi, Larry | 3 | 1 | 1 |
| Reader, D.J. | 3 | 0 | 1 |
| Bachie, Joe | 3 | 1 | 0 |
| Hill, B.J. | 3 | 1 | 1 |
| Hilton, Mike | 2 | 1 | 0 |
| Sample, Cameron | 2 | 1 | 0 |
| Apple, Eli | 2 | 1 | 0 |
| Allen, Ricardo | 1 | 0 | 0 |
| Hendrickson, Trey | 1 | 0 | 1 |
| Tupou, Josh | 1 | 0 | 0 |
| Flowers, Tre | 1 | 0 | 0 |
| Hubbard, Sam | 0 | 2 | 0 |
|
|
