The Facts: George Kittle headed to the locker room before halftime due to a leg injury.
Diehards Line:Kittle was operating as the lead receiver in San Francisco by a wide margin. Both Brandon Aiyuk and Deebo Samuel were both unable to suit up for Week 1. Jordan Reed would take over as the top tight end in San Francisco while a mess of him, Jerrick McKinnon, and Kendrick Bourne would split the top receiving job if Kittle doesn't return.